civilized (u/civilized)

civilized commented on Ex-Meta scientists debut gigantic AI protein design model nature.com/articles/d4158... · Posted by u/gmays

flobosg · a year ago

This is already a well known fact: protein structure (and consequently function) is much more conserved than sequence, mostly due to biophysical constraints.

civilized · a year ago

Forgive my ignorance - is that true even for non-synonymous mutations? They usually have a hard time disrupting the big structure?

civilized commented on Ex-Meta scientists debut gigantic AI protein design model nature.com/articles/d4158... · Posted by u/gmays

trott · a year ago

> matching less than 60% of the sequence of the most closely related fluorescent protein

> When the researchers made around 100 of the resulting designs, several were as bright as natural GFPs, which are still vastly dimmer than lab-engineered variants.

So they didn't come up with better functionality, unlike what some commentators imply. They basically introduced a bunch of mutations while preserving the overall function.

Relevant: https://en.wikipedia.org/wiki/Conservative_replacement

civilized · a year ago

If the mutations were non-synonymous, resulting in different amino acids, the fact that they keep the natural function is still kinda cool. Very much a pure research result AFAICT, but worth a little something.

civilized commented on A brief introduction to interval arithmetic buttondown.email/hillelwa... · Posted by u/zdw

ylk · a year ago

Yes it’s standard for interval arithmetic. Have a look at the interval operations section: https://en.m.wikipedia.org/wiki/Interval_arithmetic

civilized · a year ago

Yes, I see. There's a desire to map intervals pointwise through functions, but also a desire to produce intervals by all-pairs calculations, and the impossibility of representing both interpretations in one notation leads to some inconsistencies.

civilized commented on A brief introduction to interval arithmetic buttondown.email/hillelwa... · Posted by u/zdw

civilized · a year ago

> Why x^2 isn't always x * x

It turns out he's claiming they're different if x^2 is interpreted as squaring each element in the interval x, while x * x is interpreted as a cross product: the interval obtained by multiplying all pairs of elements in the interval. But I haven't ever seen anyone use x^2 to mean pointwise squaring on an interval x. Is that some kind of standard notation?

civilized commented on I am using AI to drop hats outside my window onto New Yorkers dropofahat.zone/... · Posted by u/jimhi

OkGoDoIt · a year ago

If you watch the video, it actually falls several sidewalk tiles away and he has to go pick it up. From the text of the blog, I had assumed he was using AI to actually land it directly on a person’s head, which would’ve been crazy impressive.

civilized · a year ago

Not your mistake, he does his best to imply that the hats are dropping on heads.

He's got a future in marketing.

civilized commented on Social-Media Influencers Aren't Getting Rich–They're Barely Getting By wsj.com/tech/social-media... · Posted by u/thm

Ensorceled · a year ago

Many people will do art for very little. Trying to make a living as a musician is hard because of that.

People won't work on Google products for free.

This is one of the many reasons I'm for a UBI, it makes it easier to do art without having to be a "starving artist".

civilized · a year ago

But is that "willingness to do for a low price" some kind of inherent property of artists as a group of people, or does it come from somewhere else? (The "or" here is not necessarily XOR.)

What if it all comes down to supply and demand? Maybe the supply of artists is much greater than the demand for art, while for tech products it is reversed?

civilized commented on Social-Media Influencers Aren't Getting Rich–They're Barely Getting By wsj.com/tech/social-media... · Posted by u/thm

01HNNWZ0MV43FF · a year ago

Much like other fields where one person's work can satisfy an audience of millions?

Most actors, musicians, OnlyFans people, etc., never make it. They're enticed by the few people who make it big into a career where nearly everyone is not making it at all

civilized · a year ago

In the past I have thought about it as you do. But it occurs to me now that this is also a property of tech products, isn't it? These products can be built by a small team and serve millions or billions of people. The most successful ones usually expand the team (Google Maps now employs over 7,000 people!) but it remains true that only a small team is really needed to keep the thing going.

So why are tech employees thought of differently than entertainers? Why is the math so different, such that tech employees have much more predictable and favorable employment prospects?

civilized commented on Wells Fargo Fires over a Dozen for 'Simulation of Keyboard Activity' finance.yahoo.com/news/we... · Posted by u/jmsflknr

bmmayer1 · a year ago

This seems like a silly solution to a silly problem. If you're tracking your employees' performance based on actual business metrics, who cares how many times their mouse jiggles in a given day?

civilized · a year ago

This is the real story. Mouse Jiggles a Key Performance Indicator at Major US Bank.

civilized commented on Wells Fargo Fires over a Dozen for 'Simulation of Keyboard Activity' finance.yahoo.com/news/we... · Posted by u/jmsflknr

blackeyeblitzar · a year ago

I’ve seen this issue with younger workers, who try tactics like staying off camera nearly all the time to hide their overemployment setup. It’s harder to manage people in a remote world. And no it’s not a hiring problem because people can be good at interviews and still act like this. Unfortunately they are ruining remote work for everyone else.

civilized · a year ago

While the law allows it, in my opinion there is no real moral basis for a company to lay claim to all of an employee's time. If the employee is sufficiently responsive and productive, there is no issue. If not, the company can dismiss the employee. There is no reason for the company to have more surveillance and control power over the employee than this.

civilized commented on Wells Fargo Fires over a Dozen for 'Simulation of Keyboard Activity' finance.yahoo.com/news/we... · Posted by u/jmsflknr

add-sub-mul-div · a year ago

That's appealing to emotion and outrage about something unrelated that happens to involve one of the parties, which is an organization made up of over 100,000 people. There could be bad food in their cafeteria as well, but it wouldn't make sense to invoke that here either.

civilized · a year ago

Providing objective, accurate, relevant contextual information that reasonably makes people outraged is not in itself an appeal to emotion and outrage.

The information is relevant to how we view Wells Fargo as an ethical entity. Bad food in the cafeteria would not be relevant.

u/civilized

KarmaCake day13120June 25, 2019View Original