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amphitoky commented on Human brain organoid bioprocessors now available to rent for $500 per month   tomshardware.com/pc-compo... · Posted by u/RyeCombinator
nerdjon · a year ago
So... where exactly do the neurons come from? Are these donated neurons or grown in a lab from samples?

This seems... questionable at best. Not really comfortable with the idea of this...

amphitoky · a year ago
they tend to be from donated skin cells, in fact, which are reprogrammed to produce brain tissues. see for example https://www.nature.com/articles/nprot.2014.158
amphitoky commented on Ask HN: What are your 'mental hacks' to remember small tasks?    · Posted by u/AlwaysNewb23
amphitoky · 2 years ago
Not entirely related to little tasks from meetings, but when I need to remember something eg. the next morning but I'm already in bed and dont want to get up to write it down etc, I find that a quick way to remind myself is to take something nearby, for example the book on my nightstand or just a crumpled tissue or two, and throw it on the ground where I'll see/stumble over it the next morning and think "why is this here" and then remember.
amphitoky commented on FCC refuses to scrap rule requiring ISPs to list every monthly fee   arstechnica.com/tech-poli... · Posted by u/mfiguiere
tptacek · 2 years ago
So we're clear: we're talking about labeling requirements that can change multiple times within the span of 10 blocks or so. This isn't a regional problem; it's about as local as it gets.
amphitoky · 2 years ago
so why not regulate the other end too and force more consistency and transparency in pass-through fees as well?
amphitoky commented on New York City will charge drivers going downtown   cnn.com/2023/06/10/busine... · Posted by u/rntn
eastbound · 2 years ago
One line in Paris, 2 in Toulouse, Lyon, it’s even more funny that it was built in the 1991 without drivers, truely futuristic.
amphitoky · 2 years ago
even Budapest has an autonomous line
amphitoky commented on Stanford just released a 386-page report on the state of AI   twitter.com/nonmayorpete/... · Posted by u/doener
detrites · 2 years ago
The size and speed graphs from 1950 to 2022 essentially shape an exponential but are already shown at log scale.

There must be a word for that?

amphitoky · 2 years ago
log log linear? :D
amphitoky commented on Butterfly wing patterns emerge from ancient ‘junk’ DNA   news.cornell.edu/stories/... · Posted by u/hhs
hsn915 · 3 years ago
Not knowing much about DNA, it seems weird to me that it's assumed the primary purpose of DNA is to encode for proteins. Sure, that's one of its functions, but it would be just as misguided as assuming that bits only exist to encode text, and when they encode anything else, it's seen as some extraordinary exception to the norm.
amphitoky · 3 years ago
people like to forget DNA has a 3D structure. A lot of the DNA that doesnt encode proteins might be involved, for example, in the association of 3D topological domains or conformational switches that impact chromatin accessibility. Interesting also is when sufficient factors bind to a local region of DNA to change the local chemistry and initiate phase separated domains where regulatory factors might preferrentially bind and thus drive the transcription of the few coding regions, and that's pretty cool too. Just to add some context to your bits-analogy.
amphitoky commented on Manned fighter to face autonomous drone next year   thedrive.com/the-war-zone... · Posted by u/onewhonknocks
Zenst · 5 years ago
If it's like early AI logic, fly as high as possible, say 40km which turns out is a higher flight ceiling than the attacker in many instances. But the key was the missiles had a ceiling hight of say 20 km, though if launched at 40km, they would still work upon targets flying upwards and the AI logic wouldn't think of them as a threat as those missiles don't work above 20km. Though that means they can climb to that height. Also means if they fire a missile, it won't climb to hit you. Great tactic using the limitations of the missiles to your advantage.

Things like that will be were a pilot will have an early edge, pushing those limits by fully understanding the mechanics of those limits and how they play out. Be that pushing a sonic boom shockwave to effect a small pursing drone. Those for unmanned autonomous system will be the achilles heal in much the same way early Chess AI was able to be beaten by humans thru not doing the obvious most logical move.

But if they want to tune AI for autonomous system, then doing a FTP simulator game, running the NPC drones on a server will get you lots of unique free testing and tuning of that AI done. Be much cheaper and we get a cool game to play.

amphitoky · 5 years ago
got more info on those chess games?
amphitoky commented on Scientists discover virus with no recognizable genes   sciencemag.org/news/2020/... · Posted by u/HarryHirsch
fpgaminer · 6 years ago
TIL discovering viral novelty is common:

> Viral novelty doesn’t surprise Elodie Ghedin of New York University, who looks for viruses in wastewater and in respiratory systems. More than 95% of the viruses in sewage data have “no matches to reference genomes [in databases],” she says. Like Abrahão, she says, “We seem to be discovering new viruses all the time.”

You don't know what you don't know, I guess. That also means there is an invaluable wealth of genetic knowledge out there that we haven't recorded yet. I can't wait to see what insights are revealed once we've catalogued that missing 95%.

amphitoky · 6 years ago
that's not just true for viruses, it's true for pretty much anything. we've barely scraped the surface in terms of sequencing microbes, fungi, plants, birds, fish, ..., not to even consider variation at the population (or god forbid, somatic cell) level.
amphitoky commented on Elephants Rarely Get Cancer, Now We Know Why (2015)   blogs.discovermagazine.co... · Posted by u/Osiris30
DoreenMichele · 6 years ago
As such, genetic therapies are unlikely to have an effect.

Can you back that up somehow? That doesn't sound at all right to me.

Edit: For the upvote, downvote brigade -- with zero reply so far, but this comment has gone to zero and back to one umpteen times already -- I'm genuinely curious. This isn't some kind of gotcha question.

I have a genetic disorder. I have umpteen relatives who have had cancer. I actually have a serious vested interest in better understanding how this stuff works.

amphitoky · 6 years ago
as others have said, genetic therapies for these kinds of transmissible cancers are not so effective since the cells have already acquired the cancer phenotype. The usual regulatory mechanisms which prevent unchecked proliferation occur in each individual cell, and have already been circumvented by the time cells become cancerous.

I thought I would add that what makes the tasmanian case interesting is that though the body is generally pretty good about detecting and removing foreign cells (including viruses and bacteria), somehow these contagious cancers elude this detection and are allowed to proliferate [1]. It is likely that if the tasmanian devil's immune system were able to detect the intruder cancer cells as coming from another individual, it would eradicate them with ruthless efficiency. Why these cells are able to skirt the host immune system though is a different question.

[1] https://www.ncbi.nlm.nih.gov/pubmed/28695294

amphitoky commented on Worms frozen in permafrost for up to 42,000 years come back to life   siberiantimes.com/science... · Posted by u/keeler
Alex3917 · 7 years ago
Since (some) nematodes eat poop, could we get viable megafauna DNA this way?
amphitoky · 7 years ago
just find the poop and get the DNA from there? What does the worm add?

u/amphitoky

KarmaCake day26February 11, 2014View Original