RISC-V sooner than later, the uncertainty around ARM the company due to the buyout and the whole thing with ARM China is just yuck. But honestly nothing the M1 does x86/RISC-V can't do. At this point ISA is just an ABI it's more about keeping execution pipes filled, as long as a frontend can do that it can absolutely clean up on the metrics.

Another thing although speculative: Windows 11's move to require UEFI/x64/SecureBoot could be prep for AMD and Intel to completely drop a ton of legacy support (16bit etc.) in the chips. I'd give it about 20% chance of happening, but I definitely wouldn't rule it out given you can emulate a 386 easier than you virtualize one.