Some languages are weird and do not use genders at all. People coming from those languages have a hard time dealing with gendered languages such as English.
Some people do not know what misgendering is, or even what a trans person is, or their culture might not deal with that in the same way your cultures does. Probably they have a different term for it or it is taboo for them to talk about it.
Deaf people are about the same percentage of the population as people who identify as trans. Have you learned sign language? when you approach people, do you consider they may not be able to hear you? Why is this?
There are many groups that also amount to 0.6 to 5% of the population yet are more understanding that the rest of the population may not be prepared to address their needs. Not because of malice or hate but because they simply do not know or they come from a different culture.
PHP-Markdown-Extra is the closest thing to a standard with more than GitHub-Flavored-Markdown; several other Markdown engines use its featureset as a baseline for compatibility for anything not present in GFM, even blocking the shipping of new features until after PME agrees on a syntax. So you can think of CommonMark as the lowest common denominator, GFM for an intermediate version, and PHP-Markdown-Extra as something suitable for building more advanced websites.
I'm trying to adopt as much IndieWeb as I can while still remaining a static JS-free site (except for the crappy search results page). Comments are Webmentions.
I test compatibility with a lot more than just mainstream browsers: the Tor Browser's safest mode, various article extractors, NetSurf, Ladybird, w3m, and a dozen other user-agents work well. Accessibility-wise, I'm close to WCAG 2.2 AAA compliance, and have already passed AA; I consider WCAG a starting rather than a stopping point. More on its design is in the "Meta" section.
It has long-form blog articles and short-form notes (microblogs).
My best posts are on the homepage, followed by a bunch of webrings.
It's similar to JK Rowling getting famous off the Harry Potter franchise and using that clout in a way that causes harm, prompting others to stop promoting her works and thus stop feeding her positive attention. Having read one of those books or having watched one of her movies doesn't make you a transophobe, but promoting her works gives her the means to do harm.
Moreover, the majority of soapbox instances tend to be freeze peach servers that either contain or amplify other harassers. Good soapbox instances tend to be the exception rather than the norm.
Until then, LD_PRELOAD is your friend (assuming you build with semantic interposition).