My company bought me a Xerox 1108 Lisp Machine running Interlisp D in 1982. I write a commercial product for that environment that we sold for $5K, and it was a lot of fun. I run the latest Medley releases occasionally just for nostalgia. For present day hacking enjoyment I go with SBCL Common Lisp+Emacs, or Racket, or Python when I need the ecosystem.
Xerox really did a great job creating their Lisp Machines, a joy to develop on.
Beckman Instruments got our Xerox 1108 in 1983 (and an 1186 a couple of years later). We developed Expert System commercial products in Interlisp-D but ported them to run on the PC (DOS) using the Gold Hill Common Lisp.
That was a wonderful environment to develop on. So, I'm now working on the Medley Interlisp Project!
SpinPro™ designs optimal ultracentrifugation procedures (for biology research) (Beckman manufactures and sells ultracentrifuge instruments.) SpinPro had issues with marketing, with few customers.
PepPro™ designs chemical procedures to synthesize custom peptides (small proteins). PepPro was essentially completed when Beckman Instruments dropped their entire Peptide Synthesis product line. (The PepPro user manual was in final review.)
SpinPro https://pubs.acs.org/doi/abs/10.1021/bk-1986-0306.ch023
Expert systems were so massively oversold... and it's not at all clear that any of the "super fantastic expert" systems ever did what was claimed of them.
We definitely found out that they were, in practice, extremely difficult to build and make do anything reasonable.
The original paper on Eurisko, for instance, mentioned how the author (and founder of Cyc!) Douglas Lenat, during a run, went ahead and just hand-inserted some knowledge/results of inferences (it's been a long while since I read the paper, sorry), asserting, "Well, it would have figured these things out eventually!"
Later on, he wrote a paper titled, "Why AM and Eurisko appear to work" [0].
0: https://aaai.org/papers/00236-aaai83-059-why-am-and-eurisko-...
I was one of the developers/knowledge engineers of the SpinPro™ Ultracentrifugation Expert System at Beckman Instruments, Inc. This was released in 1986, developed over about 2 years. This ran on an IBM PC (DOS)! This was a technical success, but not a commercial one. (The sales force was unfamiliar with promoting a software product, and which had little impact on their commissions vs. selling multi-thousand dollar equipment.) https://pubs.acs.org/doi/abs/10.1021/bk-1986-0306.ch023 (behind ACS paywall)
Our second Expert System was PepPro™, which designed procedures for the chemical synthesis of peptides (essentially very small proteins). This was completed and to be released in 1989, but Beckman discontinued their peptide synthesis instrument product line just two months before. This system was able to integrate end-user knowledge with the built-in domain knowledge. PepPro was recognized in the first AAAI Conference on Innovative Applications of Artificial Intelligence in 1989. https://www.aaai.org/Papers/IAAI/1989/IAAI89-010.pdf
Both of these were developed in Interlisp-D on Xerox 1108/1186 workstations, using an in-house expert system development environment, and deployed in Gold Hills Common Lisp for the PC.