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42772827 commented on Ozempic shows anti-aging effects in trial   trial.medpath.com/news/5c... · Posted by u/amichail
perching_aix · 6 months ago
I'm pretty okay with semaglutide and I understand its prospective benefits, both on a personal and societal level. My point was that the father of this person clearly has that oh-so-superior and elusive brain chemistry you suppose I have based on the account shared, so it was both immensely asinine to write what you did, as well as straight up false. That you could have went through all these other points without being an asshole about it, from the get-go. That there's a person on the other side of the screen too, and maybe, just maybe, they weren't meaning unwell, and didn't deserve a fucking brainwash about how they're actually torturing their loved one - you know, just like how people don't deserve one about how they can totally lose weight unassisted and are just being "weak willed" or whatever. That you escalated, and that thinking you're justified in doing so doesn't actually make it any fucking better.
42772827 · 6 months ago
You made the story about you, when nobody asked. Check the comment I responded to. You did exactly what people always seem to jump out of their seats to do when this drug is mentioned: crowd the conversation with anecdata about how you did it better.
42772827 commented on Ozempic shows anti-aging effects in trial   trial.medpath.com/news/5c... · Posted by u/amichail
perching_aix · 6 months ago
> Now he gets to live out the rest of his life fighting cravings, telling himself he's not allowed to enjoy food. How utterly sad.

I don't understand what drives people to write such intentionally asinine comments. Do you get off on hurting others or something?

There were quite a few foods I let go of when I decided to drop weight. Can't say I miss them much, certainly not to the extent to say something like "wow, i can't enjoy food anymore" or "now i'm fighting cravings all the time!!". And I legitimately have no interest in reintegrating them into my diet.

Turns out, some kinds of food are just dumb to consume, and my enjoyment of them is legitimately secondary. To the extent that discovering how harmful they were, they became inherently less enjoyable, and it was well possible for the habits and the cravings to subside over time. You don't try to go hit a balance with crack addiction, why would you try to hit a balance consuming 5 bazillion calorie rubbish?

Cutting out certain classes of foods from one's diet is absolutely possible and there's nothing necessarily wrong with it.

42772827 · 6 months ago
>There were quite a few foods I let go of when I decided to drop weight. Can't say I miss them much, certainly not to the extent to say something like "wow, i can't enjoy food anymore" or "now i'm fighting cravings all the time!!". And I legitimately have no interest in reintegrating them into my diet.

Your story has been told over and over and over. We get it. Congratulations. You win. You don't need GLP1s to sustain your weight loss. You don't experience food noise. You made all the right choices. Your brain and genetics are superior to the 30% of American adults who have been told to eat less and move more and still haven't managed to improve their health through weight loss.

Now that you've been properly congratulated for your superiority, are you interested at all in understanding the complex systems that prevent 100 million Americans from achieving the success you have? Like, any intellectual curiosity at all about a problem that causes untold suffering for almost one third of Americans? That costs literally billions in healthcare costs? About stress, anxiety, access to healthy foods, or the novel mechanisms by which a drug which was discovered through studying the venom of a Gila monster operates on the human gut and brain? Or are you only interested in re-telling the world how you don't have the problem that we're trying to solve?

42772827 commented on Ozempic shows anti-aging effects in trial   trial.medpath.com/news/5c... · Posted by u/amichail
strken · 6 months ago
"No free lunch" is a reasonable question to ask when evaluating medication, if it would improve the evolutionary fitness of the majority of people. I think this is behind some of the skepticism. If Ozempic is so great then how come our bodies don't just produce more GLP-1? How come we aren't like chimps, with eternally shredded bodies and cheese grater abs, provided we get the protein to support them?

I would guess that getting fat in times of plenty was a feature and not a bug in the ancestral environment, and that's why we get fat today, which is obvious if you think about it. Still, it means GLP-1 agonists are smacking into quick "is it bullshit?" heuristics for a lot of people.

The second point I haven't seen discussed is that weight loss drugs prior to GLP-1 agonists include cigarettes, which (worst case) give you cancer; stimulants, which cause your heart to fail; parasitic intestinal worms, which can kill you but more importantly are just plain gross; and mitochondrial uncouplers, which set you on fire at a cellular level. That's a long history of miracle weight loss drugs which turn out to have horrible side effects. It's not reasonable to think GLP-1 is bad just because of other drugs with different mechanisms, but it certainly causes some skepticism anyway.

42772827 · 6 months ago
> If Ozempic is so great then how come our bodies don't just produce more GLP-1? How come we aren't like chimps, with eternally shredded bodies and cheese grater abs, provided we get the protein to support them?

Evolution favored this level of GLP1, then we invented agriculture, and cooking, and bliss points. Now it’s far easier to ingest massive numbers of calories in ways that our old world systems can’t properly signal against. Evolution hasn’t caught up and maybe never will.

42772827 commented on Ozempic shows anti-aging effects in trial   trial.medpath.com/news/5c... · Posted by u/amichail
nradov · 6 months ago
Why waste money and risk side effects for a drug that's not actually needed? Changing your habits is much easier.
42772827 · 6 months ago
If changing habits were much easier, then people wouldn't be using the drug to make it easier change their habits. They would just do it.
42772827 commented on Ozempic shows anti-aging effects in trial   trial.medpath.com/news/5c... · Posted by u/amichail
nradov · 6 months ago
I don't understand. What's sad about giving up junk carbs?
42772827 · 6 months ago
Bread, sugar and potatoes exist on a spectrum from highly processed/refined (truly problematic) to minimally processed whole food versions (nutritionally valuable). There's no reason to give up minimally processed whole food versions of these.
42772827 commented on Ozempic shows anti-aging effects in trial   trial.medpath.com/news/5c... · Posted by u/amichail
throwawaylaptop · 6 months ago
Believe me, cutting out bread and sugar completely is 10x easier than some kind of lifelong moderation for a person that has struggled for it already for most of his life.

And he is extremely happy with his new sugar and bread free life of increased mobility, less pain, and much lower blood pressure. At 64, he's learning how to ride a dirtbike and doing pretty well at it.

42772827 · 6 months ago
The choice is no longer between "cutting out bread and sugar completely" and "some kind of lifelong moderation for a person that has struggled." The choice is now between "cutting out bread and sugar completely" and "removing the struggle to moderate bread and sugar."

You're clearly an advocate for your father making healthy choices. So why would you advocate against the use of a drug that makes that easier?

42772827 commented on Ozempic shows anti-aging effects in trial   trial.medpath.com/news/5c... · Posted by u/amichail
throwawaylaptop · 6 months ago
I helped my dad lose 50 lbs by finally, after 10 years, getting him to give up bread, sugar, potatoes. It took buying him 2 months of a bluetooth glucose monitor. Once he saw what certain foods do, he believed me finally. At 65 years old, healthier than I remember since he was 40 and I was a teen. It doesn't require some weird injection.
42772827 · 6 months ago
He could have lost all that weight and still had bread, sugar, and potatoes but instead he gave up what he clearly enjoyed. Now he gets to live out the rest of his life fighting cravings, telling himself he's not allowed to enjoy food. How utterly sad.
42772827 commented on The Rule of Law Is Dead in the US   thenation.com/article/pol... · Posted by u/mrtesthah
reactordev · 6 months ago
You missed the point. At the LEO level, laws are definitely being enforced
42772827 · 6 months ago
That you have the means to make that distinction inside the justice system illustrates the dichotomy. In places that never had the rule of law to begin with, what you described is the standard expectation of the individuals living it. To question it, or to comment on it at all, would be akin to asking a fish “how’s the water”? If it could talk, it’d respond, “what the hell is water”?
42772827 commented on The Rule of Law Is Dead in the US   thenation.com/article/pol... · Posted by u/mrtesthah
jleyank · 6 months ago
Overly broad title - the rule of "law" is doing just fine at lower levels. Just ask anybody with excess melanin or X chromosomes how the law's doing... At the highest level, no, there's no law at the moment, only whim's.
42772827 · 6 months ago
The rule of law generally refers to societies where everyone is subject to the same set of laws. China, for example, does not and has not had the rule of law. Instead they have rule BY law, where laws are simply to control certain people’s behavior.
42772827 commented on Denver rent is back to 2022 prices after 20k new units hit the market   denverite.com/2025/07/25/... · Posted by u/matthest
standardUser · 6 months ago
> You'll probably need to bail out recent homebuyers, who will be permanently underwater

If you buy a house for $400k, and suddenly it is worth $300k, you don't need to be "bailed out" for your purchase decision. You should have been certain that the house was worth $400k to you at the time of purchase. Otherwise you're a speculator, and we shouldn't be bailing out speculators.

It's called buyer's remorse. We accept it when it's a car or a TV, but suddenly when it's a house we're supposed to give massive government support to correct the buyer's mistake?

42772827 · 6 months ago
>It's called buyer's remorse. We accept it when it's a car or a TV, but suddenly when it's a house we're supposed to give massive government support to correct the buyer's mistake?

The difference is order of magnitude as proportion of net worth and the necessity of the purchase.

u/42772827

KarmaCake day380January 21, 2025View Original