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01100011 commented on Semaglutide improves knee osteoarthritis independant of weight loss   cell.com/cell-metabolism/... · Posted by u/randycupertino
pertymcpert · 2 days ago
That kind of damage takes many years. Do you have scans from prior years? I also discovered I have arthritis in the ankle recently and there were no pain symptoms, only joint instability and issues higher up on the leg. This was probably caused by either genetics or ankle trauma from childhood that eventually reared its head in my 30s.
01100011 · 2 days ago
My last x-ray in 11/2022 was perfect. Good joint spacing and no degenerative changes. That's over 3 years ago now though.

One thing I think changed for me was that I switched to WFH full-time and wearing crocs all day. My arches subsequently collapsed. I have joint stiffness now as well, but the x-ray didn't show anything so I think it's perhaps sinus tarsi pain from the compression due to over-pronation.

01100011 commented on Semaglutide improves knee osteoarthritis independant of weight loss   cell.com/cell-metabolism/... · Posted by u/randycupertino
sReinwald · 2 days ago
One thing I have noticed on Mounjaro is a (at least subjectively) significant decrease in impulse spending / buying random crap off Amazon. I have ADHD and that has been a real problem for quite a while - even with ADHD medication (Elvanse/Vyvanse in my case).

The part of Mounjaro that regulates the craving side of the weight loss equation (like reducing 'food noise' and the desire for sugary and fatty foods) seems to also affect other behaviors due to Mounjaro's effect on the brain's reward circuitry. I believe there are also early preliminary studies that indicate it can help with addictions like alcoholism.

Those drugs really are quite something. Shame they're so damn expensive. Insurance here in Germany is unfortunately legally prohibited from covering GLP-1 class drugs for weight loss unless you have a diabetes diagnosis.

01100011 · 2 days ago
On Wegovy(semaglutide) I haven't noticed any change in my binges or impulsiveness. Slightly worse(not dramatic) depressive episodes but that's about it.
01100011 commented on Semaglutide improves knee osteoarthritis independant of weight loss   cell.com/cell-metabolism/... · Posted by u/randycupertino
lvspiff · 2 days ago
My psychiatrist is really interested in how it affects anxiety and depression as he has now seena number of improvements from a bunch of patients (including myself) who use the drug. Im on meds for both and only after i started on monjourno did i feel a signifigant change. The food cravings gone due to the nuerological effects but the stress levels lower as it seems to be impacting seratonin levels in ways as you increase dose.
01100011 · 2 days ago
Semaglutide has a warning about not being suitable for folks with depression. I don't think I've seen any changes to my moods. I'm type-II bipolar and if anything my depression episodes are slightly worse now.
01100011 commented on Semaglutide improves knee osteoarthritis independant of weight loss   cell.com/cell-metabolism/... · Posted by u/randycupertino
01100011 · 2 days ago
Funny, after semaglutide I developed moderate arthritis in my MTP(foot) joint.

I wonder if it was gout because it seemed to come on fast. They say semaglutide shouldn't cause gout but I'm not convinced. It has some very weird effects on my hydration. I drink a fair amount of water, but specifically at night I now have to urinate a dozen times throughout the night and wake up with my mouth almost dried shut.

I've lost 10% of my bodyweight(probably >1/3 muscle, sadly) which is great and it's taking the load off my joints, but man this foot thing is a bummer. I need to find a sports Dr because most foot docs seem to take the "just stop running/hiking and switch to biking/swimming" approach which doesn't work for me.

01100011 commented on America has a tungsten problem   noleary.com/blog/posts/1... · Posted by u/noleary
01100011 · 3 days ago
There is likely a good amount of tungsten, along with other useful elements, sitting buried in US landfills.

It may take a while, but one day our old landfills will turn into mines.

01100011 commented on NIMBYs aren't just shutting down housing   inpractice.yimbyaction.or... · Posted by u/toomuchtodo
jollyllama · 6 days ago
This is probably the one issue that has the biggest online/offline divide. Online, I hear nothing but YIMBY-ism. Is there any centralized online NIMBY advocacy?
01100011 · 6 days ago
The urbanists are very, very vocal.

There's also a lot of them because many people live in cities.

Also many online communities driven by user moderation are controlled by folks with a lot of time to participate and skewed against certain segments of society. Online views often skew wildly from real life.

I've basically given up trying to find community online. Talking with real people is so much more rewarding and less frustrating.

01100011 commented on The Waymo World Model   waymo.com/blog/2026/02/th... · Posted by u/xnx
01100011 · 6 days ago
Nvidia has had this for years. What am I missing?
01100011 commented on The Great Unwind   occupywallst.com/yen... · Posted by u/jart
Trasmatta · 8 days ago
It reads exactly like a WallStreetBets "effort post" where someone has some pet theory that somehow explains the market in a way that nobody else understands, but is almost always either completely wrong, or a vast oversimplification
01100011 · 8 days ago
Fintwit is full of this crap. Fortunately it also has a few smart people who put it into context.

Financial doom porn sells well, but it's almost always wrong.

01100011 commented on xAI joins SpaceX   spacex.com/updates#xai-jo... · Posted by u/g-mork
fluoridation · 10 days ago
Why would satellites be manufactured on the moon? There's nothing on the moon. The raw materials would have to be ferried over first. What would be the point?
01100011 · 10 days ago
It would appeal to naive technofetishists, the same crowd of investors enamored by many of Elon's other impossible schemes.

The moon mfg makes significantly more sense than the hilarious plan to establish a permanent Mars base in the next 50 years, but that's not saying much.

01100011 commented on Silver plunges 30% in worst day since 1980, gold tumbles   cnbc.com/2026/01/30/silve... · Posted by u/pera
01100011 · 13 days ago
Fed independence is damaged but it was never as independent as it should have been.

No one since Volcker has been a real hawk. It hasn't led to hyperinflation, just a continual debasement that has served many purposes.

u/01100011

KarmaCake day9027May 11, 2018View Original