> "The intranasal dose of TriSb92 that should be administered to susceptible persons prior to events involving a risk for SARS-CoV-2 exposure remains to be established but is likely to be substantially lower than extrapolation of our current data on mice that were challenged by inoculation of the rather massive amount of 2x105 PFU of SARS-CoV-2 into their respiratory tract."
Side effects might be an issue but that should show up in well-designed clinical trials. It sounds like something that people working in infectious clinical settings might want to use, maybe immunocompromised people who have to go out in public, but otherwise, for general use seems iffy in terms of efficacy.
The former is a measure of how effective something is, in absolute terms.
OP might mean that because the protection isn't complete or permanent, it might not make sense for an otherwise healthy person to use it unless they expect to be in close quarters with a lot of possibly-sick people. Too early to say, ofc.
There's already some nasal sprays around that supposedly protect against Covid-19 in a similar way. However many places online just echo the copy from the manufacturers about the efficiency. Has anyone tried those sprays and can share their experience?
I use an iota-carrageenan nasal spray that has clinical evidence showing it's effective at reducing the duration of common cold, as well as some protection from COVID. Obviously, the COVID research is a bit flimsier. It's also cheap, and carrageenan is pretty inert. I use it any time I'm around big groups of people for more than a few minutes.
If you're talking about the nitric oxide spray, my friend used it at a conference and got COVID anyway, so where n=1, it didn't work. But then again, almost all of us got COVID. I was masked the whole time, he used the spray, others took no preventative measures, and it didn't seem to matter much.
Individual experiences volunteered online are a very low value signal when assessing the efficacy of a medicine. This is why homeopathy exists.
I'm not blindly trusting of corporations, but the manufacturer's claims are likely to be a better guide than anecdotes, at least in a country with reasonable regulation of medicines and medical claims.
Since the initial outbreak of SARS-CoV-2 I have kept bottles of Betadine nasal spray around. They say "clinically proven to reduce cold symptoms on the packaging," always seemed reasonable to think it might work as well against this coronavirus as all the others.
Povidone-iodine (taken nasally or as a gargle) kills viruses and bacteria. All types, including Covid, with 99.9% effectiveness according to numerous studies.
Has worked this way (and safely) since the 1950's.
Given that it's effective, and cheap to produce it's no wonder big pharma lobbied so hard for their own expensive partial treatments.
Yep did the gargle as well both times I had COVID. Tried nasal irrigation with the diluted form but it was just too much to handle so I used NeilMed instead. n=1 caveats, but both cases (the first one Delta) were mild.
Betadine gargle is 1% povidone-iodine. As a nasal spray dilute by 50% with water. Active protection for 3-4 hours minimum (again according to numerous studies)
University of Western Australia Study finds nasal spray could aid battle against COVID
Nasodine Nasal Spray is based on povidone-iodine, the same active ingredient found in Betadine throat gargle, and has been in development for almost a decade as a treatment for the common cold. Laboratory experiments showed a 15-second exposure to the nasal spray reduced infectivity of SARS-CoV-2 by 99.97 per cent, while a 60-second exposure completely eliminated viral infectivity.
A subsequent pilot study of six COVID-19 patients, who were shedding the virus from the nose, looked at whether the laboratory results translated to people.
The trial showed that a single Nasodine dose (four sprays per nostril) reduced viral shedding in five of the six subjects (83 per cent) at five minutes after the dose, with an overall 79 per cent reduction in viral shedding at one hour after the dose.
It sounds like the nasal spray has a molecular structure based on the shape of a key molecule unique to Covid. Is it possible that your housemate thought they were experiencing regular hayfever but actually it was hayfever + fighting off a mild Covid infection at the same time? That's the only way I can imagine to explain what you described.
It could be that any nasal spray would have had that affect, even just a weak water only one. Considering that nasal irrigation is a treatment for hay fever, I can see it having some effect even if the medicine part isn’t applicable.
Intranasal administration of just 5 or 50 micrograms of TriSb92 as early as 8 h before but also 4 h after SARS-CoV-2 challenge can protect from infection.
Source: https://www.nature.com/articles/s41467-023-37290-6
Readit News
https://www.biorxiv.org/content/10.1101/2021.12.28.474326v1....
> "The intranasal dose of TriSb92 that should be administered to susceptible persons prior to events involving a risk for SARS-CoV-2 exposure remains to be established but is likely to be substantially lower than extrapolation of our current data on mice that were challenged by inoculation of the rather massive amount of 2x105 PFU of SARS-CoV-2 into their respiratory tract."
Side effects might be an issue but that should show up in well-designed clinical trials. It sounds like something that people working in infectious clinical settings might want to use, maybe immunocompromised people who have to go out in public, but otherwise, for general use seems iffy in terms of efficacy.
The former is a measure of how effective something is, in absolute terms.
OP might mean that because the protection isn't complete or permanent, it might not make sense for an otherwise healthy person to use it unless they expect to be in close quarters with a lot of possibly-sick people. Too early to say, ofc.
[1] common cold: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880062/#:~:tex.... [2] covid: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8493111/
It's one of the biggest reasons I don't want to return to working in an office any time soon.
Dead Comment
I'm not blindly trusting of corporations, but the manufacturer's claims are likely to be a better guide than anecdotes, at least in a country with reasonable regulation of medicines and medical claims.
not really.
they're both equally poor.
even if the manufacturer has clinical trials, they often need to be treated with skepticism.
(i.e. All of it is equally bad/biased "data")
The pandemic is real, and we need to trust the experts here
- https://www.pandemblock.com/products
- https://www.nature.com/articles/s41467-023-37290-6
Q: how would this be to take, if it's ever human certified? Are there similar nasal immunity products, using similar molecular mechanisms?
Nasodine Nasal Spray is based on povidone-iodine, the same active ingredient found in Betadine throat gargle, and has been in development for almost a decade as a treatment for the common cold. Laboratory experiments showed a 15-second exposure to the nasal spray reduced infectivity of SARS-CoV-2 by 99.97 per cent, while a 60-second exposure completely eliminated viral infectivity.
The trial showed that a single Nasodine dose (four sprays per nostril) reduced viral shedding in five of the six subjects (83 per cent) at five minutes after the dose, with an overall 79 per cent reduction in viral shedding at one hour after the dose.https://www.uwa.edu.au/news/Article/2022/February/Study-find...
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> In laboratory animal studies, a molecule known as TriSb92...