A key challenge with Alzheimer’s is there is no good mouse model for the disease. While some approximate the phenotype, it’s not clear that the disease model as commonly studied in mice matches well with mechanisms of the human disease. There’s some thinking in the field that this could be a key reason why so many treatments have appeared very promising in mice and haven’t panned out in humans.
Readit Newstbenst commented on Alzheimer’s disease can be reversed in animal models? Study case.edu/news/new-study-s... · Posted by u/thunderbong
Beautifully written and worth the read. And the screensaver nerd snipe is epic.
tbenst commented on Does current AI represent a dead end? bcs.org/articles-opinion-... · Posted by u/jnord
As a neuroscientist, my biggest disagreement with the piece is the author’s argument for compositionality over emergence. The former makes me think of Prolog and lisp, while the later is a much better description for a brain. I think ermergence is a much more promising direction for AGI than compositionality.
tbenst commented on Scientists decipher two-photon vision phys.org/news/2024-11-sci... · Posted by u/bookofjoe
tbenst commented on Scientists decipher two-photon vision phys.org/news/2024-11-sci... · Posted by u/bookofjoe
This is a well known phenomenon. It accounts for example in the flash perceived when someone inadvertently looks at an infrared class 5 laser and is blinded
tbenst commented on Functional ultrasound through the skull brainhack.vercel.app/fus... · Posted by u/lawrenceyan
This is fun, and the modeling is cool for sure, but it's well known that ultrasound can be used with surgical precision in the human brain.
Focused ultrasound is already used for non-invasive neuromodulation. Raag Airan's lab at Stanford does this for example using ultrasound uncaging.
https://www.frontiersin.org/journals/neuroscience/articles/1...
https://www.sciencedirect.com/science/article/pii/S089662731...
Also see the work by Urvi Vyas, eg
https://pubmed.ncbi.nlm.nih.gov/27587047/
I don't mean to discount the cool imaging-related reconstruction of a point spread function, but rather to say that ultrasound attenuation through the skull an soft tissue has already been well characterized and it's not a surprise that it is viable to pass through.
tbenst commented on Hell Freezes Over as AMD and Intel Come Together for x86 servethehome.com/hell-fre... · Posted by u/rbanffy
This is mostly a recognition of the shared threat that ARM poses to both AMD and Intel.
ARM took embedded first, then mobile, then gaming (on mobile and handhelds), then Macs, and now it is making real inroads into Windows laptops (e.g. Snapdragon X Elite) and servers (e.g. Graviton.)
The next shoe to drop would be a high-end gaming PC that can take an NVIDIA or AMD graphics card powered by a Snapdragon X Elite-like ARM chip.
Another shoe to drop would be a super-computer powered by ARM chips instead of x86. I don't think that has happened yet?
After that, the last refuge of x86 is in legacy software that hasn't been natively ported to ARM. But there will be fewer and fewer cases of this as the years go by. For now I think it will be mostly games.
x86 is under serious threat.
The Nvidia GH200/GB200 “superchips” are all ARM processors. Seems likely that some of the next generation of foundation models will be trained on ARM
tbenst commented on Hack Your Way to Scientific Glory (2016) projects.fivethirtyeight.... · Posted by u/wjb3
I know the exercise was to p-hack, but instead I decided to one-shot my attempt at the most reasonable model from first principals:
- given that we are looking at a national scale, use only national politicians
- use the components from Macroeconomics 101: exclude inflation as that’s on the Fed, exclude stocks as too conflated with FX and international investing alternatives
- don’t needlessly withhold data
Tried one hypothesis, so p-value of 0.04 is accurate. Still OK to explore if you Bonferroni correct the p-Val afterwards
Printing pure copper (99.9%) is possible since years with SLM process using lasers with an appropriate wavelength
Any references for 99.9% density with SLM copper? My understanding is that pure copper SLM printing is less frequently done as doesn’t work well with the infrared lasers on most machines, requires high heat & speed, and has more porosity than other alloys. It’s also hard to print so that it’s strong, conductive and heat stable.
I think there’s still quite active research in the area, though, and no doubt there’s a lot going on that I don’t know! https://www.sciencedirect.com/science/article/pii/S026412752...