Physics allows practical applications of mathematics, whether using sine/cosine to explain wave motion or complex calculation of celestial objects, like planetary orbits. Yet it still cannot explain quantum mechanics, i.e. interactions of subatomic particles because there the general laws of physics do not work. So basically it just comes down to how much of physics knowledge that humanity has obtained up to now really explains the universe - and it seems there are still vasts gaps in science that still needs to be filled.