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dnhz commented on Computer Simulations of Proteins Help Unravel Why Chemotherapy Resistance Occurs   news.stonybrook.edu/unive... · Posted by u/rbanffy
dnhz · 3 years ago
Terrible pop sci title that makes the work sound a bigger deal than it is. I thought that evolution of cancer under drug treatment would be described. But a more accurate title would be, Computer simulations of proteins show molecular mechanism of particular resistance mutations to imatinib that were previously characterized to increase ligand dissociation kinetics.

That is, certain mutations in the protein that the drug imatinib inhibits enable cancer cells to be more resistant to the drug. A previous experimental study by the researchers found that these mutations increase the rate of drug unbinding from the protein. The study here describes computer simulations of the protein and explains why the mutations lead to increased dissociation kinetics. An advanced algorithm was used to sample ligand unbinding events in simulation.

dnhz commented on The afterlife of used hotel soap   thehustle.co/the-surprisi... · Posted by u/Anon84
dnhz · 3 years ago
84% of guests use the TV? I thought hotels were for visiting somewhere.
dnhz commented on World’s first octopus farm stirs ethical debate   reuters.com/business/envi... · Posted by u/hhs
AngryData · 4 years ago
To me the most important questions are, does living a farm style life cause them undue distress and harm, and will they realize they are on a farm instead of just some weird octopus community.

For example, the cows I own I can keep on my land and they are perfectly content to munch grass around the different pastures throughout the year as they are rotated, and have free clean shelter in the barn and free hay in the winter. The only thing containing them is a thin strand of wire which they can (and have) easily walked through at any point in time without even trying, usually to reach an especially tall clump of weeds on the other side. For most of their life they are under basically zero stress due to protections from the environment and predators and have no desire to leave or look for more. They don't feel trapped and keeping them contained is more of a suggestion that they don't wander off and get lost. While at the end it sucks they will be distressed when loaded up in a trailer and taken down the road to the slaughterhouse, but they aren't thinking "Oh my god they are going to kill and eat me!",they are just bewildered by the wild experience of being driven down a road in a trailer, then let out in a new place with maybe some other cows around, and are instantly KOed when they are to be slaughtered.

I would have very different feelings about it if they lived in shitty life trapped in a little cage always hoping and trying to find a way out, feared humans as they came around stealing their friends away from them at random times assuming they were being eaten. And I do feel that way about, and don't buy, a lot of factory meat for the contained caged lives they experience when there are known better, healthier, more sustainable, and more ethical ways of caring for farm animals that goes back thousands of years.

dnhz · 4 years ago
Even still, your cows live a fraction of their natural lifespans. A few years as opposed to 10+
dnhz commented on AirPods don't “just work”   philip.design/blog/airpod... · Posted by u/knowingathing
mrtranscendence · 4 years ago
The most annoying thing about my AirPods Pro, which I generally like very much ... my phone starts playing music from its speakers when I take the AirPods out of my ears (and was not previously listening to music). Not all the time, but maybe 15% of the time, enough to be annoying. I have no idea what's going on. I've tried googling it, but nobody else seems to be having this problem. I've combed through settings but nothing seems applicable. I think I'm stuck with it.
dnhz · 4 years ago
I don’t have AirPods but this sometimes happens to me when I turn off my Bluetooth headphones. Usually it’s Spotify that begins playing on my computer. I agree that google searching has been unhelpful.
dnhz commented on     · Posted by u/19h
vaughan · 4 years ago
> root cause

There is a bug for 5500M GPU that causes 18W sustained power draw with one external monitor. It should normally be 5W or so.

The throttling is due to your VRM chips overheating. There is no temp sensor for this exposed to the user.

The VRM chips have no cooling. The high GPU watt draw pushes the temps of the VRMs above their thermal limits with no cooling.

The solution is to put thermal pads on your VRMs to dissipate the heat to the backplate. Completely resolved my issue.

Disabling TurboBoost can also help. Running fans at max speed at all times too because Mac is slow to ramp them up when load increases.

Apparently the 5600M doesn’t have this issue and the 5500M bug is fixed in Monterey. But the thermal pad mod is still amazing. Apple couldn’t do it stock, because there are regulations about hot a backplate can get related to risk of burns.

dnhz · 4 years ago
Hmm so 5300m also has no issues?
dnhz commented on Org Mode 9.5   orgmode.org/Changes.html... · Posted by u/todsacerdoti
dnhz · 4 years ago
I use org mode by having a single file and using it as a notebook/journal. I use todos to mark important entries.

I’m comfortable with org mode operations and formatting although I don’t know how to use drawers or properties or what’s the point of archiving. I like using org-ref, and I see a version of that has been added officially this version.

I never learned a more clever way of using org mode. Any tips or guides?

dnhz commented on Welcoming our first riders in San Francisco   blog.waymo.com/2021/08/we... · Posted by u/EvgeniyZh
joebob42 · 4 years ago
But the bar to be better than a human in this case is also wickedly low.

I basically can't do this. If it was absolutely necessary I would go out there and drive like 5 mph and be terrified the whole time, but otherwise I would just treat whatever I needed to drive to in a snowstorm at night as temporarily inaccessible. I have lived in places where it snowed in winter before.

dnhz · 4 years ago
But the use case is not the middle of the night but perhaps during evening rush hour where it gets dark after 5 PM in the winter, and a storm began in the afternoon.
dnhz commented on Welcoming our first riders in San Francisco   blog.waymo.com/2021/08/we... · Posted by u/EvgeniyZh
marwatk · 4 years ago
I suspect it will know where the lane markings are better than human drivers. They are mapped ahead of time and the car can likely localize itself via other landmarks to determine where they are without being able to see them.

The harder part is driving like a human and detecting that a path has been made in the middle of two lanes in heavy snow and not obeying the lines at all.

dnhz · 4 years ago
The first idea seems like it would require a lot a lot of data stored in the car. Is it feasible? And even so, to be that dependent on matching up with existing pre-mapped data suggests a system that would be quite slow to roll out across a country.
dnhz commented on London civil servant's bus odyssey sparks Twitter storm   bbc.co.uk/news/uk-england... · Posted by u/Kaibeezy
dnhz · 4 years ago
> "I also really like timetables and I like the logistics of putting things together."

I enjoy that too. It's also essential if you don't have a car. I think it's a shame that Amtrak no longer has timetables for download. Maybe it's to hide the sad fact that there are only 10-15 trains per day in one direction on the northeast corridor.

dnhz commented on How green is blue hydrogen?   onlinelibrary.wiley.com/d... · Posted by u/geox
jessaustin · 4 years ago
We will know that "green" hydrogen is nearly feasible when they stop talking about hydrogen and just admit that ammonia, which doesn't cause embrittlement and stores energy more densely than hydrogen, is what they meant all along.
dnhz · 4 years ago
But hydrogen is the prerequisite for ammonia, and ammonia still needs cryogenic infrastructure?

u/dnhz

KarmaCake day235February 7, 2018View Original