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apike commented on Novo Nordisk's Canadian Mistake   science.org/content/blog-... · Posted by u/jbm
0cf8612b2e1e · 2 months ago
I had never considered it-what makes a drug prescription vs OTC? Every substance has safety concerns(dose makes the poison), so with a lot of the financial gone, will the GLPs ever not require a prescription?
apike · 2 months ago
The FDA (or equivalent in the relevant country) regulates whether an approved drug requires a prescription based on the safety profile. To be approved for OTC, there is a much higher bar in terms of ease of misuse, side effects, and so on.
apike commented on Vancouver Stock Exchange: Scam capital of the world (1989) [pdf]   scamcouver.wordpress.com/... · Posted by u/thomassmith65
FloorEgg · 2 months ago
I've raised from angels in Vancouver. There is definitely a VSE hangover culture there. During the grind I had some strange experiences.

One involved an argument with the prospective investor over the share price. In their view it had to be between 20 and 50 cents. They didn't care about the valuation, or typical investment terms, only the share price.

Another invited us to an IPO party for another company they invested in (TSX if I remember correctly). At this party we learned that the company that IPO'd had less than 100k revenue (and huge losses). They were out of business within 3 years.

I guess it is hard for old dogs to learn new tricks... They made their millions off pump and dumps in VSE days and just didn't stop playing those games even long after the exchange shut down.

apike · 2 months ago
My experience raising in Vancouver is that there are two angel communities.

There is an easier to find Vancouver-centric investor group that behaves as a you describe. Many of these investors didn’t come up as tech founders. I was advised not to waste time with them, so I don't know if there are some gems in the rough there or not.

Then there is a quieter group that got their capital from building serious tech businesses. This group spends more time connecting outside Vancouver – Bay Area mostly, but also Toronto and globally. These folks do write early-stage cheques and can be very helpful advisors, but they're not full-time angels who are spending time on deal flow. They're mostly focused on building their next thing, so it’s more difficult to earn their attention.

So yes there are questionable actors, but there are also very legit folks doing great work, and it’s possible to go to an event or dinner party that only really has one or the other. Hope that’s helpful to any other founders building in Vancouver!

apike commented on Figma Slides Is a Beautiful Disaster   allenpike.com/2025/figma-... · Posted by u/tobr
greysteil · 7 months ago
PM at Figma here (for dev tools, not slides).

What happened to Allen here sucks. I've messaged the team so we can dig into this specific case. More generally, we know that Slides needs to be bulletproof when presenting, and nothing less than that is acceptable.

As an FYI, we _do_ use Figma Slides internally for pretty much everything, from internal meetings to major events. As a PM I use it every week, and our internal feedback channel for Slides is super active with folks like me requesting improvements. Figma is also a pretty unique place, where it's more likely our senior leadership request quality improvements than chase for deadlines - we know how critical the user experience is. We don't always get it right, but when we don't we're committed to fixing it.

apike · 7 months ago
Thanks Grey – other than the presenting-at-an-event flow I do really did like the Figma Slides experience, so this is great to hear. The world is better off with a strong Figma.
apike commented on Compare OpenAI Models   platform.openai.com/docs/... · Posted by u/hakaneskici
apike · 9 months ago
This is interesting, but the values could use some refinement:

  gpt-4o: speed 3/5
  gpt-4.5-preview: speed 3/5
  gpt-3.5-turbo: speed 2/5
In practice 3.5 turbo is, what, 5-10x faster than 4.5 preview?

apike commented on JavaScript Fatigue Strikes Back   allenpike.com/2025/javasc... · Posted by u/ingve
ulrischa · 10 months ago
I wonder why the author did not mention PHP wgen he writes about the cool kids choosing the old technology. For me this is obvious: get a ultra cheap webhosting throw your PHP, HTML and frontend JS on and forget about server maintenance
apike · 10 months ago
I mentioned Ruby and Python in this vein, but PHP with Laravel would count in my book too. That said, PHP may be nearing the stage Java has gotten to, where it’s well-understood but is perceived as outdated enough that it causes hiring and retention friction.
apike commented on Narrative Jailbreaking for Fun and Profit   interconnected.org/home/2... · Posted by u/tobr
nameless912 · a year ago
This seems like a "turtles all the way down" kinda solution... What's to say you won't fool the supervisor LLM?
apike · a year ago
While this can be done in principle (it's not a foolproof enough method to, for example, ensure an LLM doesn't leak secrets) it is much harder to fool the supervisor than the generator because:

1. You can't get output from the supervisor, other than the binary enforcement action of shutting you down (it can't leak its instructions)

2. The supervisor can judge the conversation on the merits of the most recent turns, since it doesn't need to produce a response that respects the full history (you can't lead the supervisor step by step into the wilderness)

3. LLMs, like humans, are generally better at judging good output than generating good output

u/apike

KarmaCake day1476April 8, 2009
About
I'm Allen Pike.

I'm co-founder of Forestwalk Labs, where we're building tools for AI engineers.

Previously, I was co-founder of Steamclock, and before that a Software Engineer at Apple. I also make podcasts, like It Shipped That Way.

   https://allenpike.com
   https://forestwalk.ai
   https://itshipped.fm

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