The main issue is mission assurance. Using the stack or the heap means your variables aren't always at the same memory address. This can be bad if a particular memory cell has failed. If every variable has a fixed address, and one of those addresses goes bad, a patch can be loaded to move that address and the mission can continue.
Where do you place the variables then? as global variables? and how do you detect if a memory cell has gone bad?
A good example of what I'm talking about is a program that I was peripherally involved with about 15 years ago. The lead wanted to abstract the mundane details from the users (on the ground), so they would just "register intent" with the spacecraft, and it would figure out how to do what was wanted. The lead also wanted to eliminate features such as "memory dump", which is critical to the anomaly resolution process. If I had been on that team, I would have raised hell, but I wasn't, and at the time, I needed that team lead as an ally.
You could have two copies of the OS mapped to different memory regions. The CPU would boot with the first copy, if it fails watchdog would trigger and the CPU could try to boot the second copy.