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_spduchamp · 20 days ago
You can find Bill Atkinson's open-source instructions for Jaguar (5-MeO-DMT) Vape Pens from a link here: https://boingboing.net/2025/07/10/apples-bill-atkinson-creat...
__MatrixMan__ · 20 days ago
I think this paper is about N,N-DMT. 5-MeO is a different beast. Although I've run across N,N in vape pen form so this is still a relevant delivery mechanism.

In terms of ergonomics pens can't be beat, though if you'd rather go from 0 to escape velocity on a single hit, "the machine" is the way to go (https://wiki.dmt-nexus.me/The_Machine)

Lucasoato · 20 days ago
> We find that DMT shifts the normally dominant alpha oscillations towards a quieter subcritical state, increasing entropy while reducing complexity, and that this shift correlates with intensity of disruption of the sense of self.

Wait, is this a good or a bad thing? Asking for a friend.

awakeasleep · 20 days ago
Its terrible if you’re trying to drive or operate machinery
isoprophlex · 20 days ago
... Unless said machinery is provided to you by the machine elves, of course.
cluckindan · 20 days ago
1) Absolutely nobody is going to take heavy psychedelics if they are driving or operating heavy machinery, and if they are, they are either very misinformed or simply don’t care to the point of malice. Driving or operating while impaired is a crime in itself.

2) The effects of DMT wear off in 15-30 minutes, which is why it’s called ”the businessman’s lunch”. Subjectively, however, a person may experience decades of time pass.

ireadmevs · 20 days ago
Well, just by reading the abstract I can’t tell if the results are positive or not. But glad to see more research being done on this area.
victor22 · 20 days ago
Who over here in HN has tried DMT?
isoprophlex · 20 days ago
I did a LOT of that. We made our own in undergrad; depending on audacity and effort we made stuff ranging from beautifully clear, crystalline needles to stuff that looked like satans' earwax. Extremely memorable stuff, that at that moment in life, was a very good thing to happen to me in order to learn how to connect with my feelings.
boppo1 · 20 days ago
I did it once. Felt like my consciousness rocketed "up" out of my body, but not up through physical space, through some 'adjacent' space. Then I saw/felt "infinity". There was no time, and I saw a hundu-esque god/goddess with infinite arms. I had no interest in eastern religion prior. Not disinterested either. I just didn't think about it, the way I don't think about golf.

It was a neat thing to experience.

Hnus · 20 days ago
I saw exactly the same infinite arms thing with zero prior interest in religion. It took me to place “I was once before and should know well” other entities protested because why bother when he needs to go back soon. Then I came back to my room and had no idea what to do with that experience.
stanfordkid · 20 days ago
I have done Ayahuasca. I think it's dangerous to say it is "healing"... it's a window not a door. You have to be careful, some personalities will develop psychosis and disconnection from reality. You will certainly end up above where you started but there may be a deep trench you have to walk through. Especially amongst type-A highly IQ and rationality driven people this is very likely IMO.
temp0826 · 20 days ago
I assure you this is mostly a set/setting problem and why it's recommended to do with experienced (and more importantly, grounded) facilitators. It can leave you pretty open and suggestable, drinking with a group of lost souls and escapists is not recommended especially if you're new to it. (I've worked at traditional retreat centers and have drank hundreds of times; it's a little funny when someone comes in expecting to be able to build a story and further their escape then have their bubbles burst by a grounded point of view)
chiefgeek · 20 days ago
I’ve sat with 5MeO-DMT over a dozen times, always in the form of Bufo flake from the toad. It has been one of the most transformational and healing modality I’ve encountered. I have a low dose Jaguar (synthetic) pen that I use occasionally.

I’ve also used NN from a pen. It gave me a strange body load and intense kaleidoscopic visuals.

lifty · 18 days ago
Did you make the pen yourself? And is it possible to have a breakthrough with it?
1MachineElf · 20 days ago
Small doses. Never enough to disassociate. Only lots of LSD and 4-HO-DET ever did that to me.

The most striking memory with DMT was at night seeing a moonlight cloud full of skulls staring back down at me. I frequently saw skulls in any texture.

It was very long ago. Unfortunately the dealer was raided.

It left a noticable residue in the simplistic vape we had and a few subsequent uses still carried traces of it.

cluckindan · 20 days ago
Haven’t tried it, but I’ve been told by decades of research that it is present in many common plants, mostly in low but in certain cases substantial quantities, and merely needs to be extracted and purified via recrystallization.
survirtual · 20 days ago
DMT saved my life.
bn-l · 20 days ago
How do you mean? Can you go into detail?
CuriouslyC · 20 days ago
TL;DR: DMT makes brainwaves simpler and more disordered. I have a scientific background and I'm quite familiar with DMT, but I'm struggling to take anything meaningful from this.
isoprophlex · 20 days ago
They found that DMT disrupts the brainwave patterns that, if you squint a bit, belong to what Hofstadter calls the "strange loop" of consciousness. In a sense it is as you'd expect.
bitmasher9 · 20 days ago
I think the terminology is hacked to produce the most scary looking headline while saying the most mundane and expected things.
hiddencost · 20 days ago
I think they're using technical language that you're aware of, and you're misinterpreting the title of a research paper.